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Peptide record

TPDB08356

Antibacterial Anticancer Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08356
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 SATPdb dbACP Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GLVGTLLGHIGKAILS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C71H125N19O19
RNDCEQMFPWY
GL
1548.89
10.10
2
0
8
+1
-1.43
1.250
170.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
2
I
4
L
1
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 2 L: 4 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
16 reviewed residue count
C71H125N19O19 sequence-only estimate (linear, free termini)
1548.89 sequence-only estimate (linear, free termini)
10.10 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-1.43 sequence-only estimate (linear, free termini)
1.250 sequence-only estimate (linear, free termini)
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8-16 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM
Evidence 2 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM), S. maltophilia clinical isolates B32/
Evidence 3 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

A. baumannii clinical isolates NM75

Source & Reference

dbAMP

Other

rains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM), S. maltophilia clinical isolates B32/1 B32/4 U8908 B5/5 B6/2 (MIC 31-62 uM). Active agai
Evidence 4 Activity

Activity

MIC
Antibacterial
6.2-12.5 µM

Target

v. pruni

Source & Reference

dbAMP

Other

1-62 uM). Active against plant pathogens X. axonopodis pv. vesicatoria and X. arboricola pv. pruni (MIC 6.2-12.5 uM) ( Camó C et al. 2018 ). Also active against non-small cell lung adenocarcinoma A549 cells
Evidence 5 Activity

Activity

MIC
Antifungal
8-16 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM
Evidence 6 Activity

Activity

MIC
Antifungal
62.5 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM), S. maltophilia clinical isolates B32/
Evidence 7 Activity

Activity

MIC
Antifungal
62.5 µM

Target

A. baumannii clinical isolates NM75

Source & Reference

dbAMP CAFPdb Antifungipept

Other

rains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM), S. maltophilia clinical isolates B32/1 B32/4 U8908 B5/5 B6/2 (MIC 31-62 uM). Active agai
Evidence 8 Activity

Activity

MIC
Antifungal
6.2-12.5 µM

Target

v. pruni

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1-62 uM). Active against plant pathogens X. axonopodis pv. vesicatoria and X. arboricola pv. pruni (MIC 6.2-12.5 uM) ( Camó C et al. 2018 ). Also active against non-small cell lung adenocarcinoma A549 cells
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
169±7 µM
Hemolytic Cytotoxic
50% Hemolysis | 169±7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae) | Peptides | 2014
Evidence 10 Activity

Activity

84±1.8% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
84±1.8% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide KSL-W and analogues: Promising agents to control plant diseases. | Peptides | 2018
Evidence 11 Activity

Activity

HC50
Toxicity
169
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=169 ± 7 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2014 Jun 56:132-40.