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Peptide record

TPDB08356

Antibacterial Anticancer Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08356
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 SATPdb dbACP Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GLVGTLLGHIGKAILS
Physicochemical Analysis
C71H125N19O19
RNDCEQMFPWY
GL
1548.89
10.10
2
0
8
+1
-0.70
1.250
170.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
2
I
4
L
1
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 2 L: 4 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
16
C71H125N19O19
1548.89
10.10
+1
-0.70
1.250
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8-16 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM
Evidence 2 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM), S. maltophilia clinical isolates B32/
Evidence 3 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

A. baumannii clinical isolates NM75

Source & Reference

dbAMP

Other

rains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM), S. maltophilia clinical isolates B32/1 B32/4 U8908 B5/5 B6/2 (MIC 31-62 uM). Active agai
Evidence 4 Activity

Activity

MIC
Antibacterial
6.2-12.5 µM

Target

v. pruni

Source & Reference

dbAMP

Other

1-62 uM). Active against plant pathogens X. axonopodis pv. vesicatoria and X. arboricola pv. pruni (MIC 6.2-12.5 uM) ( Camó C et al. 2018 ). Also active against non-small cell lung adenocarcinoma A549 cells
Evidence 5 Activity

Activity

MIC
Antifungal
8-16 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM
Evidence 6 Activity

Activity

MIC
Antifungal
62.5 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM), S. maltophilia clinical isolates B32/
Evidence 7 Activity

Activity

MIC
Antifungal
62.5 µM

Target

A. baumannii clinical isolates NM75

Source & Reference

dbAMP CAFPdb Antifungipept

Other

rains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM75 (MIC 62.5 uM), S. maltophilia clinical isolates B32/1 B32/4 U8908 B5/5 B6/2 (MIC 31-62 uM). Active agai
Evidence 8 Activity

Activity

MIC
Antifungal
6.2-12.5 µM

Target

v. pruni

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1-62 uM). Active against plant pathogens X. axonopodis pv. vesicatoria and X. arboricola pv. pruni (MIC 6.2-12.5 uM) ( Camó C et al. 2018 ). Also active against non-small cell lung adenocarcinoma A549 cells
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
169±7 µM
Hemolytic Cytotoxic
50% Hemolysis | 169±7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae) | Peptides | 2014
Evidence 10 Activity

Activity

84±1.8% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
84±1.8% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide KSL-W and analogues: Promising agents to control plant diseases. | Peptides | 2018
Evidence 11 Activity

Activity

HC50
Toxicity
169
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=169 ± 7 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2014 Jun 56:132-40.