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Peptide record

TPDB08355

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08355
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GCSRWIIGIHGQICRD
Physicochemical Analysis
C77H124N26O21S2
ANELKMFPTYV
I
1814.11
8.30
3
1
5
+1
0.98
0.056
97.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
310.07
4
Residue Composition
number
0
A
2
R
0
N
1
D
2
C
0
E
1
Q
3
G
1
H
4
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 2 E: 0 Q: 1 G: 3 H: 1 I: 4 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
16
C77H124N26O21S2
1814.11
8.30
+1
0.98
0.056
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
75 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 3 Activity

Activity

MIC
Antibacterial
9.4 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 4 Activity

Activity

MIC
Antibacterial
9.4 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

e against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 5 Activity

Activity

MIC
Antifungal
>100 µM

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
75 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 7 Activity

Activity

MIC
Antifungal
9.4 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 8 Activity

Activity

MIC
Antifungal
9.4 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

e against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 9 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

E.coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml).
Evidence 10 Activity

Activity

MIC
Antiparasitic
75 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 11 Activity

Activity

MIC
Antiparasitic
9.4 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

active against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 12 Activity

Activity

MIC
Antiparasitic
9.4 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

e against E.coli (MIC>100 uM), S. aureus (MIC 75 ug/ml), B. subtilis (MIC 9.4 ug/ml), and C. albicans (MIC 9.4 ug/ml). Also histamine release.
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 14 Activity

Activity

(1.6±1.2)% degranulation
Toxicity
50 µg/mL
Cytotoxic
(1.6±1.2)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007