TPDB

3D PDB MODEL

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TPDB ID TPDB08353

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FIGKLISAASGLLSHL

FASTA

>TPDB08353|Antibacterial;Antifungal|length=16
FIGKLISAASGLLSHL

Formula C76H127N19O20

Absent Amino Acids RNDCEQMPTWYV

Common Amino Acids L

Mass 1626.96

PI 10.10

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +1

Boman Index -1.97

Hydrophobicity 1.269

Aliphatic Index 158.75

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

2

A

0

R

0

N

0

D

0

C

0

E

0

Q

2

G

1

H

2

I

4

L

1

K

0

M

1

F

0

P

3

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 4 K: 1 M: 0 F: 1 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 0

Length

16

Formula

C76H127N19O20

Mass

1626.96

PI

10.10

Net Charge

+1

Boman Index

-1.97

Hydrophobicity

1.269

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 38.4 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 38.4 uM), S. aureus (MIC 9.5 uM), and C.albicans (MIC 150 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 38.4 uM), S. aureus (MIC 9.5 uM), and C.albicans (MIC 150 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 150 µM

Target

Target Organism C.albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 38.4 uM), S. aureus (MIC 9.5 uM), and C.albicans (MIC 150 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 38.4 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 38.4 uM), S. aureus (MIC 9.5 uM), and C.albicans (MIC 150 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 38.4 uM), S. aureus (MIC 9.5 uM), and C.albicans (MIC 150 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 150 µM

Target

Target Organism C.albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 38.4 uM), S. aureus (MIC 9.5 uM), and C.albicans (MIC 150 uM).