Back to search

Peptide record

TPDB08352

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard

16 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08352

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

SFPFFPPGICKRLKRC

FASTA

>TPDB08352|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=16
SFPFFPPGICKRLKRC

Formula C89H138N24O18S2

Absent Amino Acids ANDEQHMTWYV

Common Amino Acids FP

Mass 1896.34

PI 10.58

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +4

Boman Index 0.35

Hydrophobicity -0.069

Aliphatic Index 48.75

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.59

Polar Residues 3

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 2 M: 0 F: 3 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C89H138N24O18S2

Mass

1896.34

10.58

Net Charge

Boman Index

0.35

Hydrophobicity

-0.069

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 35 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 35 uM) but not S.aureus adn C.albicans (MIC >160 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >160 µM

Target

Target Organism C.albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 35 uM) but not S.aureus adn C.albicans (MIC >160 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 35 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 35 uM) but not S.aureus adn C.albicans (MIC >160 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >160 µM

Target

Target Organism C.albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 35 uM) but not S.aureus adn C.albicans (MIC >160 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 35 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 35 uM) but not S.aureus adn C.albicans (MIC >160 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >160 µM

Target

Target Organism C.albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 35 uM) but not S.aureus adn C.albicans (MIC >160 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 35 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against E. coli (MIC 35 uM) but not S.aureus adn C.albicans (MIC >160 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >160 µM

Target

Target Organism C.albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 35 uM) but not S.aureus adn C.albicans (MIC >160 uM).

Evidence 9 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Limnonectins: a new class of antimicrobial peptides from the skin secretion of the Fujian large-headed frog (Limnonectes fujianensis). | Biochimie | 2011

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.21396976] It exhibits no hemolytic activity at a concentration of up to 160 µM.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochimie. 2011 Jun 93(6):981-987.