Peptide record

TPDB08345

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard

16 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08345

Activity

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia dbACP Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ILGKLLSTAAGLLSNL

FASTA

>TPDB08345|Antibacterial;Anticancer;Antidiabetic;Antifungal;Antiparasitic;Antiviral;Cell-penetrating Peptides;Hemolysis;Toxicity|length=16
ILGKLLSTAAGLLSNL

Formula C72H130N18O21

Absent Amino Acids RDCEQHMFPWYV

Common Amino Acids L

Mass 1583.93

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +1

Boman Index -2.18

Hydrophobicity 1.275

Aliphatic Index 183.12

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

Amino Acid Distribution

A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 6 K: 1 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C72H130N18O21

Mass

1583.93

10.10

Net Charge

Boman Index

-2.18

Hydrophobicity

1.275

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against primarily G+ bacteria such as S. aureus (MIC 50 uM). Also, this peptide stimulated the rate of insulin release from BRIN-BD11 clonal beta cel

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against primarily G+ bacteria such as S. aureus (MIC 50 uM). Also, this peptide stimulated the rate of insulin release from BRIN-BD11 clonal beta cel

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against primarily G+ bacteria such as S. aureus (MIC 50 uM). Also, this peptide stimulated the rate of insulin release from BRIN-BD11 clonal beta cel

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against primarily G+ bacteria such as S. aureus (MIC 50 uM). Also, this peptide stimulated the rate of insulin release from BRIN-BD11 clonal beta cel

Evidence 5 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Hemolysis

Activity Measurement 135 µM

Hemolysis Raw

[Ref:19463738] LC50 = 135 µM against human erthrocytes.

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Peptides. 2009 Jun 30(6):1069-1073.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 6 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 135-140 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 135-140 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 7 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 135 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:19463738] LC50 = 135 µM against human erthrocytes.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2009 Jun 30(6):1069-1073.

Evidence 8 Hemolysis

Activity

Activity Measurement 135 µM

Activity Endpoint LC50

Hemolysis Raw

[Ref:19463738] LC50 = 135 µM against human erthrocytes.

Detail Source Activity Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Peptides. 2009 Jun 30(6):1069-1073.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.