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Peptide record

TPDB08335

Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08335
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIMSSLMKKLAAHIAK
Physicochemical Analysis
C75H135N21O19S2
RNDCEQFPTWYV
AK
1699.15
10.84
4
0
9
+3
1.49
0.556
116.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
2
I
2
L
3
K
2
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 2 L: 2 K: 3 M: 2 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C75H135N21O19S2
1699.15
10.84
+3
1.49
0.556
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
53-63 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
HYL exhibited weak antimicrobial activity against several strains of pathogenic bacteria S. aureus (MIC 53-63 uM) S. epidermidis (MIC 13 uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and m
Evidence 2 Activity

Activity

MIC
Antibacterial
13 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

crobial activity against several strains of pathogenic bacteria S. aureus (MIC 53-63 uM) S. epidermidis (MIC 13 uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and moderate activity against C.
Evidence 3 Activity

Activity

MIC
Antibacterial
15 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

eral strains of pathogenic bacteria S. aureus (MIC 53-63 uM) S. epidermidis (MIC 13 uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and moderate activity against C. albicans (MIC 18 uM),
Evidence 4 Activity

Activity

MIC
Antibacterial
20-68 µM

Target

Pseudomonas aeruginosa 5482

Source & Reference

dbAMP DRAMP

Other

genic bacteria S. aureus (MIC 53-63 uM) S. epidermidis (MIC 13 uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and moderate activity against C. albicans (MIC 18 uM), but its hemo.lytic activity agains
Evidence 5 Activity

Activity

MIC
Antibacterial
18 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and moderate activity against C. albicans (MIC 18 uM), but its hemo.lytic activity against human red blood cells was low (HL50 >400 uM). Update
Evidence 6 Activity

Activity

MIC
Antifungal
53-63 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
HYL exhibited weak antimicrobial activity against several strains of pathogenic bacteria S. aureus (MIC 53-63 uM) S. epidermidis (MIC 13 uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and m
Evidence 7 Activity

Activity

MIC
Antifungal
13 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

crobial activity against several strains of pathogenic bacteria S. aureus (MIC 53-63 uM) S. epidermidis (MIC 13 uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and moderate activity against C.
Evidence 8 Activity

Activity

MIC
Antifungal
15 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

eral strains of pathogenic bacteria S. aureus (MIC 53-63 uM) S. epidermidis (MIC 13 uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and moderate activity against C. albicans (MIC 18 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
20-68 µM

Target

Pseudomonas aeruginosa 5482

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

genic bacteria S. aureus (MIC 53-63 uM) S. epidermidis (MIC 13 uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and moderate activity against C. albicans (MIC 18 uM), but its hemo.lytic activity agains
Evidence 10 Activity

Activity

MIC
Antifungal
18 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM) E. coli (MIC 15 uM), P. aeruginosa 5482 (MIC 20-68 uM) and moderate activity against C. albicans (MIC 18 uM), but its hemo.lytic activity against human red blood cells was low (HL50 >400 uM). Update
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
>400 µM
Hemolytic Cytotoxic
50% Hemolysis | >400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. | J Nat Prod | 2016
Evidence 12 Activity

Activity

LC50
Toxicity
400 µM
Hemolytic
Hemolytic_activity: [Ref.26998557] LC50>400 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 2016 Apr 22 79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.