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Peptide record

TPDB08331

Antibacterial Anticancer Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08331
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VARGWKRKCPLFGKGG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C80H130N26O17S1
NDEQHIMSTY
G
1760.14
11.56
5
0
5
+5
1.59
-0.606
48.75
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
3.12
1
Residue Composition
number
1
A
2
R
0
N
0
D
1
C
0
E
0
Q
4
G
0
H
0
I
1
L
3
K
0
M
1
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 1 K: 3 M: 0 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
16 reviewed residue count
C80H130N26O17S1 sequence-only estimate (linear, free termini)
1760.14 sequence-only estimate (linear, free termini)
11.56 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
1.59 sequence-only estimate (linear, free termini)
-0.606 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

0.35% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0.35% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing potent antimicrobial peptides by disulphide linked dimerization and N-terminal lipidation to increase antimicrobial activity and membrane perturbation: Structural insights into lipopolysaccharide binding. | J Colloid Interface Sci | 2016
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
0% Hemolysis | 250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control. | Sci Rep | 2015