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Peptide record

TPDB08327

Antibacterial Anticancer Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08327
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 SATPdb dbACP AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GLVGTLLGHIGKAILG
Physicochemical Analysis
C70H123N19O18
RNDCEQMFPSWY
G
1518.86
10.10
2
0
8
+1
-0.82
1.275
170.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
1
H
2
I
4
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 1 I: 2 L: 4 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
16
C70H123N19O18
1518.86
10.10
+1
-0.82
1.275
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8-16 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM8, NM35, and NM
Evidence 2 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM8, NM35, and NM75 (MIC 62.5 uM), S. maltophilia clinica
Evidence 3 Activity

Activity

MIC
Antibacterial
3.1-6.2 µM

Target

v. vesicatoria

Source & Reference

dbAMP

Other

32/1 B32/4 U8908 B5/5 B6/2) (MIC 31-62 uM). Active against plant pathogens X. axonopodis pv. vesicatoria (MIC 3.1-6.2 uM) ( Camó C et al. 2018 ). Showed a poor hemolysis of human erythrocytes (LC50 >160 uM). Als
Evidence 4 Activity

Activity

MIC
Antifungal
8-16 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM8, NM35, and NM
Evidence 5 Activity

Activity

MIC
Antifungal
62.5 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against reference strains S. aureus and S. epidermidis (MIC 8-16 uM), E. faecalis, C. albicans (MIC 62.5 uM), A. baumannii clinical isolates NM8, NM35, and NM75 (MIC 62.5 uM), S. maltophilia clinica
Evidence 6 Activity

Activity

MIC
Antifungal
3.1-6.2 µM

Target

v. vesicatoria

Source & Reference

dbAMP CAFPdb Antifungipept

Other

32/1 B32/4 U8908 B5/5 B6/2) (MIC 31-62 uM). Active against plant pathogens X. axonopodis pv. vesicatoria (MIC 3.1-6.2 uM) ( Camó C et al. 2018 ). Showed a poor hemolysis of human erythrocytes (LC50 >160 uM). Als
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
167±8 µM
Hemolytic Cytotoxic
50% Hemolysis | 167±8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae) | Peptides | 2014
Evidence 8 Activity

Activity

86±2.4% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
86±2.4% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide KSL-W and analogues: Promising agents to control plant diseases. | Peptides | 2018
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
404±11 µM
Hemolytic Cytotoxic
50% Hemolysis | 404±11 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae) | Peptides | 2014
Evidence 10 Activity

Activity

HC50
Toxicity
167
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=167 ± 8 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2014 Jun 56:132-40.
Evidence 11 Activity

Activity

HC50
Toxicity
404
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=404 ± 11 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2014 Jun 56:132-40.