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Peptide record

TPDB08324

Antibacterial Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08324
Antibacterial Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FIGALLRPALKLLAGK
Physicochemical Analysis
C81H141N21O17
NDCEQHMSTWYV
L
1681.14
11.64
3
0
10
+3
-1.49
1.063
165.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
3
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
5
L
2
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 5 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C81H141N21O17
1681.14
11.64
+3
-1.49
1.063
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.ce
Evidence 2 Activity

Activity

MIC
Antibacterial
256 µM

Target

P.aeruginosa

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-3
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

M. luteus

Source & Reference

dbAMP

Other

gainst Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-32 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.cerevisiae

Source & Reference

dbAMP

Other

uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-32 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.ce
Evidence 7 Activity

Activity

MIC
Antifungal
256 µM

Target

P.aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and
Evidence 8 Activity

Activity

MIC
Antifungal
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-3
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

gainst Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-32 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
128 µM

Target

S.cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-32 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.ce
Evidence 12 Activity

Activity

MIC
Antiparasitic
256 µM

Target

P.aeruginosa

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and
Evidence 13 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-3
Evidence 14 Activity

Activity

MIC
Antiparasitic
4 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

gainst Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-32 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
128 µM

Target

S.cerevisiae

Source & Reference

dbAMP 3.0

Other

uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-32 uM).
Evidence 16 Activity

Activity

MIC
Antiviral
32 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.ce
Evidence 17 Activity

Activity

MIC
Antiviral
256 µM

Target

P.aeruginosa

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and
Evidence 18 Activity

Activity

MIC
Antiviral
16 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-3
Evidence 19 Activity

Activity

MIC
Antiviral
4 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

gainst Gram- E. coli (MIC 32 uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-32 uM).
Evidence 20 Activity

Activity

MIC
Antiviral
128 µM

Target

S.cerevisiae

Source & Reference

dbAMP 3.0

Other

uM), P.aeruginosa (MIC 256 uM), Gram+ S. aureus (MIC 16 uM), M. luteus (MIC 4 uM), yeast S.cerevisiae (MIC 128 uM), and parasite T. brucei (LC95 16-32 uM).
Evidence 21 Activity

Activity

50% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
50% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 22 Activity

Activity

IC50
Toxicity
128 µM
Cytotoxic
IC50 | 128 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 23 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.