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Peptide record

TPDB08320

Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08320
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPFLIPALTSLISSL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C86H138N16O21
RNDCEQGHKMWYV
L
1732.14
6.02
0
0
10
-0
-1.84
1.819
176.88
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
5
L
0
K
0
M
2
F
2
P
3
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 5 K: 0 M: 0 F: 2 P: 2 S: 3 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C86H138N16O21 sequence-only estimate (linear, free termini)
1732.14 sequence-only estimate (linear, free termini)
6.02 sequence-only estimate (linear, free termini)
-0 sequence-only estimate (linear, free termini)
-1.84 sequence-only estimate (linear, free termini)
1.819 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against S. aureus (MIC 50 uM) and weakly active against C. albicans (MIC 150 uM)
Evidence 2 Activity

Activity

MIC
Antibacterial
150 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

active against S. aureus (MIC 50 uM) and weakly active against C. albicans (MIC 150 uM)
Evidence 3 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against S. aureus (MIC 50 uM) and weakly active against C. albicans (MIC 150 uM)
Evidence 4 Activity

Activity

MIC
Antifungal
150 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against S. aureus (MIC 50 uM) and weakly active against C. albicans (MIC 150 uM)
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Senegalin: a novel antimicrobial/myotropic hexadecapeptide from the skin secretion of the African running frog, Kassina senegalensis. | Amino Acids | 2013