TPDB

3D PDB MODEL

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TPDB ID TPDB08320

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPFLIPALTSLISSL

FASTA

>TPDB08320|Antibacterial;Antifungal;Toxicity|length=16
FLPFLIPALTSLISSL

Formula C86H138N16O21

Absent Amino Acids RNDCEQGHKMWYV

Common Amino Acids L

Mass 1732.14

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 10

Net Charge -0

Boman Index -4.42

Hydrophobicity 1.819

Aliphatic Index 176.88

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

2

I

5

L

0

K

0

M

2

F

2

P

3

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 5 K: 0 M: 0 F: 2 P: 2 S: 3 T: 1 W: 0 Y: 0 V: 0

Length

16

Formula

C86H138N16O21

Mass

1732.14

PI

6.02

Net Charge

-0

Boman Index

-4.42

Hydrophobicity

1.819

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against S. aureus (MIC 50 uM) and weakly active against C. albicans (MIC 150 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 150 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against S. aureus (MIC 50 uM) and weakly active against C. albicans (MIC 150 uM)

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against S. aureus (MIC 50 uM) and weakly active against C. albicans (MIC 150 uM)

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 150 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against S. aureus (MIC 50 uM) and weakly active against C. albicans (MIC 150 uM)

Evidence 5 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Senegalin: a novel antimicrobial/myotropic hexadecapeptide from the skin secretion of the African running frog, Kassina senegalensis. | Amino Acids | 2013