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Peptide record

TPDB08306

Antibacterial Anticancer Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08306
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb dbAMP
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
LGGIVSAVKKIVDFLG
Physicochemical Analysis
C76H130N18O20
RNCEQHMPTWY
GV
1615.98
9.88
2
1
9
+1
0.54
1.281
158.12
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
3
G
0
H
2
I
2
L
2
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
16
C76H130N18O20
1615.98
9.88
+1
0.54
1.281
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram+ E.faecalis PCM 2673 (MIC 128 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gr
Evidence 2 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP

Other

active against Gram+ E.faecalis PCM 2673 (MIC 128 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 u
Evidence 3 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

S.pneumoniae ATCC 49619

Source & Reference

dbAMP

Other

t Gram+ E.faecalis PCM 2673 (MIC 128 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 32
Evidence 4 Activity

Activity

MIC
Antibacterial
64-128 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP

Other

aureus ATCC 25923 or 9144 (MIC 64 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 32 ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

umoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 32 ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albi
Evidence 6 Activity

Activity

MIC
Antibacterial
256 µg/mL

Target

P.aeruginosa ATCC 9027

Source & Reference

dbAMP

Other

E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 32 ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.g
Evidence 7 Activity

Activity

MIC
Antibacterial
256 µg/mL

Target

A.niger ATCC 16404

Source & Reference

dbAMP

Other

, K. pneumoniae ATCC 700603 (MIC 32 ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 256 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP

Other

ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 256 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
256 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

dbAMP

Other

ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 256 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram+ E.faecalis PCM 2673 (MIC 128 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gr
Evidence 11 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against Gram+ E.faecalis PCM 2673 (MIC 128 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 u
Evidence 12 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

S.pneumoniae ATCC 49619

Source & Reference

dbAMP CAFPdb Antifungipept

Other

t Gram+ E.faecalis PCM 2673 (MIC 128 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 64 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 32
Evidence 13 Activity

Activity

MIC
Antifungal
64-128 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aureus ATCC 25923 or 9144 (MIC 64 ug/ml), S.pneumoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 32 ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi
Evidence 14 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

umoniae ATCC 49619 (MIC 128 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 32 ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albi
Evidence 15 Activity

Activity

MIC
Antifungal
256 µg/mL

Target

P.aeruginosa ATCC 9027

Source & Reference

dbAMP CAFPdb Antifungipept

Other

E. coli ATCC 25922 or 23506 (MIC 64-128 ug/ml), K. pneumoniae ATCC 700603 (MIC 32 ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.g
Evidence 16 Activity

Activity

MIC
Antifungal
256 µg/mL

Target

A.niger ATCC 16404

Source & Reference

dbAMP CAFPdb Antifungipept

Other

, K. pneumoniae ATCC 700603 (MIC 32 ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 256 ug/ml).
Evidence 17 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ug/ml), P.aeruginosa ATCC 9027 (MIC 256 ug/ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 256 ug/ml).
Evidence 18 Activity

Activity

MIC
Antifungal
256 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ml), fungi A.niger ATCC 16404 (MIC 256 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 256 ug/ml).
Evidence 19 Activity

Activity

0% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides. | Amino Acids | 2017
Evidence 20 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2003 Mar 270(6):1141-53.