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Peptide record

TPDB08300

Antibacterial Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08300
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
IISTIGKLVKWIIKTV
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C88H154N20O20
ARNDCEQHMFPY
I
1812.31
10.84
3
0
9
+3
-0.98
1.219
182.50
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
3.03
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
5
I
1
L
3
K
0
M
0
F
0
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 5 L: 1 K: 3 M: 0 F: 0 P: 0 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
16 reviewed residue count
C88H154N20O20 sequence-only estimate (linear, free termini)
1812.31 sequence-only estimate (linear, free termini)
10.84 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.98 sequence-only estimate (linear, free termini)
1.219 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
11 µM
Hemolytic Cytotoxic
50% Hemolysis | 11 | µM | target cell: Guinea pig erythrocytes

Target

Guinea pig erythrocytes

Source & Reference

NA
DBAASP
Generation of analogs having potent antimicrobial and hemolytic activities with minimal changes from an inactive 16-residue peptide corresponding to the helical region of Staphylococcus aureus delta-toxin. | Prot Eng | 1995
Evidence 2 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis