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Peptide record

TPDB08291

TP Antibacterial Anticancer Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08291
TP
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ASVVNKLTGGVAGLLK
Physicochemical Analysis
C68H123N19O20
RDCEQHIMFPWY
GLV
1526.84
10.60
2
0
8
+2
0.89
0.850
140.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
3
L
2
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 2 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
16
C68H123N19O20
1526.84
10.60
+2
0.89
0.850
Free
L
Linear
Free
Antimicrobial
Tibetan swine
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.5-10 µM

Target

Escherichia coli ATCC 25922 or Chloramphenicol-resistant

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli ATCC 25922 or Chloramphenicol-resistant (MIC 2.5-10 uM) and S. aureus ATCC 29213 or CMCC 26003 or MRSA (MIC 10-20 uM), A. hydrophila CGMCC1.1802
Evidence 2 Activity

Activity

MIC
Antibacterial
10-20 µM

Target

Staphylococcus aureus ATCC 29213 or CMCC 26003 or MRSA

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 or Chloramphenicol-resistant (MIC 2.5-10 uM) and S. aureus ATCC 29213 or CMCC 26003 or MRSA (MIC 10-20 uM), A. hydrophila CGMCC1.1802 (MIC 5 uM), S. Typhimurium CMCC 2212 (MIC 5-10 uM), L-monocyto
Evidence 3 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

S. Typhimurium CMCC 2212

Source & Reference

dbAMP

Other

us ATCC 29213 or CMCC 26003 or MRSA (MIC 10-20 uM), A. hydrophila CGMCC1.1802 (MIC 5 uM), S. Typhimurium CMCC 2212 (MIC 5-10 uM), L-monocytogenes CMCC 53-5 (MIC> 80 uM), M. scarlatinae ATCC 19615 (MIC 20 uM), P. aerugi
Evidence 4 Activity

Activity

MIC
Antibacterial
20 µM

Target

M. scarlatinae ATCC 19615

Source & Reference

dbAMP

Other

IC 5 uM), S. Typhimurium CMCC 2212 (MIC 5-10 uM), L-monocytogenes CMCC 53-5 (MIC> 80 uM), M. scarlatinae ATCC 19615 (MIC 20 uM), P. aeruginosa CMCC B10102 (mic 10 uM), Pasteurella CMCC 464 (MIC 20 uM), H. parasuis CMC
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa CMCC B10102

Source & Reference

dbAMP

Other

5-10 uM), L-monocytogenes CMCC 53-5 (MIC> 80 uM), M. scarlatinae ATCC 19615 (MIC 20 uM), P. aeruginosa CMCC B10102 (mic 10 uM), Pasteurella CMCC 464 (MIC 20 uM), H. parasuis CMCC 3728 (MIC 10-20 uM), and S. Pullorum
Evidence 6 Activity

Activity

MIC
Antibacterial
10-20 µM

Target

H. parasuis CMCC 3728

Source & Reference

dbAMP

Other

615 (MIC 20 uM), P. aeruginosa CMCC B10102 (mic 10 uM), Pasteurella CMCC 464 (MIC 20 uM), H. parasuis CMCC 3728 (MIC 10-20 uM), and S. Pullorum CMCC 519 (MIC 20 uM). Anticancer: human MKN-45 cells (IC50 4.7uM) and NB
Evidence 7 Activity

Activity

MIC
Antibacterial
20 µM

Target

S. Pullorum CMCC 519

Source & Reference

dbAMP

Other

(mic 10 uM), Pasteurella CMCC 464 (MIC 20 uM), H. parasuis CMCC 3728 (MIC 10-20 uM), and S. Pullorum CMCC 519 (MIC 20 uM). Anticancer: human MKN-45 cells (IC50 4.7uM) and NB4 (IC50 11.5 uM).
Evidence 8 Activity

Activity

IC50
Antibacterial
4.7 µM

Target

human MKN-45 cells

Source & Reference

dbAMP

Other

, H. parasuis CMCC 3728 (MIC 10-20 uM), and S. Pullorum CMCC 519 (MIC 20 uM). Anticancer: human MKN-45 cells (IC50 4.7uM) and NB4 (IC50 11.5 uM).
Evidence 9 Activity

Activity

IC50
IC50 = 4.686 µM
Anticancer
4.686 µM

Target

Gastric Cancer
MKN-45
Stomach

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 10 Activity

Activity

IC50
IC50 = 11.479 µM
Anticancer
11.479 µM

Target

Leukemia Cancer
NB-4
Blood

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018
Evidence 11 Activity

Activity

MIC
Antifungal
2.5-10 µM

Target

Escherichia coli ATCC 25922 or Chloramphenicol-resistant

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli ATCC 25922 or Chloramphenicol-resistant (MIC 2.5-10 uM) and S. aureus ATCC 29213 or CMCC 26003 or MRSA (MIC 10-20 uM), A. hydrophila CGMCC1.1802
Evidence 12 Activity

Activity

MIC
Antifungal
10-20 µM

Target

Staphylococcus aureus ATCC 29213 or CMCC 26003 or MRSA

Source & Reference

dbAMP Antifungipept

Other

Active against E. coli ATCC 25922 or Chloramphenicol-resistant (MIC 2.5-10 uM) and S. aureus ATCC 29213 or CMCC 26003 or MRSA (MIC 10-20 uM), A. hydrophila CGMCC1.1802 (MIC 5 uM), S. Typhimurium CMCC 2212 (MIC 5-10 uM), L-monocyto
Evidence 13 Activity

Activity

MIC
Antifungal
5-10 µM

Target

S. Typhimurium CMCC 2212

Source & Reference

dbAMP Antifungipept

Other

us ATCC 29213 or CMCC 26003 or MRSA (MIC 10-20 uM), A. hydrophila CGMCC1.1802 (MIC 5 uM), S. Typhimurium CMCC 2212 (MIC 5-10 uM), L-monocytogenes CMCC 53-5 (MIC> 80 uM), M. scarlatinae ATCC 19615 (MIC 20 uM), P. aerugi
Evidence 14 Activity

Activity

MIC
Antifungal
20 µM

Target

M. scarlatinae ATCC 19615

Source & Reference

dbAMP Antifungipept

Other

IC 5 uM), S. Typhimurium CMCC 2212 (MIC 5-10 uM), L-monocytogenes CMCC 53-5 (MIC> 80 uM), M. scarlatinae ATCC 19615 (MIC 20 uM), P. aeruginosa CMCC B10102 (mic 10 uM), Pasteurella CMCC 464 (MIC 20 uM), H. parasuis CMC
Evidence 15 Activity

Activity

MIC
Antifungal
10 µM

Target

Pseudomonas aeruginosa CMCC B10102

Source & Reference

dbAMP Antifungipept

Other

5-10 uM), L-monocytogenes CMCC 53-5 (MIC> 80 uM), M. scarlatinae ATCC 19615 (MIC 20 uM), P. aeruginosa CMCC B10102 (mic 10 uM), Pasteurella CMCC 464 (MIC 20 uM), H. parasuis CMCC 3728 (MIC 10-20 uM), and S. Pullorum
Evidence 16 Activity

Activity

MIC
Antifungal
10-20 µM

Target

H. parasuis CMCC 3728

Source & Reference

dbAMP Antifungipept

Other

615 (MIC 20 uM), P. aeruginosa CMCC B10102 (mic 10 uM), Pasteurella CMCC 464 (MIC 20 uM), H. parasuis CMCC 3728 (MIC 10-20 uM), and S. Pullorum CMCC 519 (MIC 20 uM). Anticancer: human MKN-45 cells (IC50 4.7uM) and NB
Evidence 17 Activity

Activity

MIC
Antifungal
20 µM

Target

S. Pullorum CMCC 519

Source & Reference

dbAMP Antifungipept

Other

(mic 10 uM), Pasteurella CMCC 464 (MIC 20 uM), H. parasuis CMCC 3728 (MIC 10-20 uM), and S. Pullorum CMCC 519 (MIC 20 uM). Anticancer: human MKN-45 cells (IC50 4.7uM) and NB4 (IC50 11.5 uM).
Evidence 18 Activity

Activity

IC50
Antifungal
4.7 µM

Target

human MKN-45 cells

Source & Reference

dbAMP Antifungipept

Other

, H. parasuis CMCC 3728 (MIC 10-20 uM), and S. Pullorum CMCC 519 (MIC 20 uM). Anticancer: human MKN-45 cells (IC50 4.7uM) and NB4 (IC50 11.5 uM).
Evidence 19 Activity

Activity

<10% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
<10% Hemolysis | 160 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Isolation and characterisation of a novel antibacterial peptide from a native swine intestinal tract-derived bacterium. | Int J Antimicrob Agents | 2017
Evidence 20 Activity

Activity

10% Hemolysis
Toxicity
320 µM
Hemolytic Cytotoxic
10% Hemolysis | 320 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Isolation and characterisation of a novel antibacterial peptide from a native swine intestinal tract-derived bacterium. | Int J Antimicrob Agents | 2017
Evidence 21 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 22 Activity

Activity

50% Cell death
Toxicity
>128 µM
Cytotoxic
50% Cell death | >128 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 23 Activity

Activity

50% Cell death
Toxicity
>128 µM
Cytotoxic
50% Cell death | >128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis. | Front Microbiol | 2022
Evidence 24 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Mouse erythrocytes: <10% Hemolysis=160µM 10% Hemolysis=320µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Antimicrob Agents. 2017 Apr 49(4):427-436.