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Peptide record

TPDB08290

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08290
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 AI4AVP DRAVP 2.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKKVLKAAAK
Physicochemical Analysis
C86H152N22O18
RNDCEQGHIMFPSY
K
1782.29
11.12
5
0
10
+5
0.39
0.344
140.62
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
308.59
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
5
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 5 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
16
C86H152N22O18
1782.29
11.12
+5
0.39
0.344
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

A. baumannii

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against A. baumannii (MIC 6.25 ug/ml). MBC: 12.5 ug/ml. Virus: it inhibited Zika virus (ZIKV) (EC50 0.82 ug/ml ) ( Haddad et al
Evidence 2 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

A. baumannii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against A. baumannii (MIC 6.25 ug/ml). MBC: 12.5 ug/ml. Virus: it inhibited Zika virus (ZIKV) (EC50 0.82 ug/ml ) ( Haddad et al
Evidence 3 Activity

Activity

MIC
Antiparasitic
6.25 µg/mL

Target

A. baumannii

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
active against A. baumannii (MIC 6.25 ug/ml). MBC: 12.5 ug/ml. Virus: it inhibited Zika virus (ZIKV) (EC50 0.82 ug/ml ) ( Haddad et al
Evidence 4 Activity

Activity

MIC
Antiviral
6.25 µg/mL

Target

A. baumannii

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
active against A. baumannii (MIC 6.25 ug/ml). MBC: 12.5 ug/ml. Virus: it inhibited Zika virus (ZIKV) (EC50 0.82 ug/ml ) ( Haddad et al
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
10±0.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 10±0.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
15±3 µM
Hemolytic Cytotoxic
50% Hemolysis | 15±3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives | J Biol Chem | 2002
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
57±3 µM
Hemolytic Cytotoxic
50% Hemolysis | 57±3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 8 Activity

Activity

50% Cytotoxicity
Toxicity
30.19 µM
Cytotoxic
50% Cytotoxicity | 30.19 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In Vitro Antiviral Activity of Dermaseptin S(4) and Derivatives From Amphibian Skin Against Herpes Simplex Virus Type 2 | J Med Virol | 2013
Evidence 9 Activity

Activity

50% Cytotoxicity
Toxicity
37.30 µg/mL
Cytotoxic
50% Cytotoxicity | 37.30 | µg/mL | target cell: Human microglial cells HMC3

Target

Human microglial cells HMC3

Source & Reference

NA
DBAASP
Evaluation of the antiviral activity of new dermaseptin analogs against Zika virus | Biochem Biophys Rep | 2024
Evidence 10 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.15780876]P4-CCR5 cells:CC50>100 µM.

Source & Reference

NA
DRAMP
Virology. 2005 Apr 10 334(2):264-75.
Evidence 11 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis