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Peptide record

TPDB08289

Antibacterial Anticancer Cell-penetrating Peptides Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08289
Antibacterial Anticancer Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia MLCPP 2.0 PD_Hemolysis
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWFRIQLQIRRWRNRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C105H170N42O20
ADCEGHKMPSTYV
R
2340.77
13.18
7
0
6
+7
6.24
-1.763
73.12
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
4.70
3
Residue Composition
number
0
A
7
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C105H170N42O20 sequence-only estimate (linear, free termini)
2340.77 sequence-only estimate (linear, free termini)
13.18 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
6.24 sequence-only estimate (linear, free termini)
-1.763 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

HC50
Hemolysis
39
[Ref.23085001] HC50=39±1.4 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2013 Feb 1828(2):223-232. doi: 10.1016/j.bbamem.2012.10.010.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
39±1.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 39±1.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure. | Biochim Biophys Acta | 2013
Evidence 3 Activity

Activity

HC50
Toxicity
39
Hemolytic
Hemolytic_activity: [Ref.23085001] HC50=39±1.4 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Feb 1828(2):223-232. doi: 10.1016/j.bbamem.2012.10.010.
Evidence 4 Hemolysis

Activity

39
HC50
[Ref.23085001] HC50=39±1.4 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Biochim Biophys Acta. 2013 Feb 1828(2):223-232. doi: 10.1016/j.bbamem.2012.10.010.
DRAMP4
PD_Hemolysis