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Peptide record

TPDB08287

7Arg PenArg Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08287
7Arg PenArg
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RQIRIWFQNRRMRWRR
Physicochemical Analysis
C104H168N42O20S1
ADCEGHLKPSTYV
R
2358.81
13.18
7
0
6
+7
1.57
-1.881
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
466.34
3
Residue Composition
number
0
A
7
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
0
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C104H168N42O20S1
2358.81
13.18
+7
1.57
-1.881
Free
L
Amphipathic Cationic and amphipathic Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
In vitro
CCCCCCGGGCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HEK293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphipathic
Synthetic
Nucleic acid (Plasmid DNA)
Cytoplasm
PenArg showed good transfection capability
Endocytosis
In vitro
CCCCCCGGGCCCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells

Assay & Model

Male Sprague-Dawley rats (252±7 g)
Male Sprague-Dawley rats (252±7 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Insulin
PenArg enhanced the insulin permeation to the same degree as penetratin at both pH 5 and pH 7.4,
In vitro and in vivo
CCCCSCCCCCSSSCCC
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure. | Biochim Biophys Acta | 2013
Evidence 5 Activity

Activity

HC50
Toxicity
128 µM
Hemolytic
Hemolytic_activity: [Ref.23085001] HC50>128 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Feb 1828(2):223-232. doi: 10.1016/j.bbamem.2012.10.010.
Additional Detail Fields 1 fields
CCCCCCGGGCCCCCCC CCCCSCCCCCSSSCCC