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Peptide record

TPDB08280

Antibacterial Anticancer Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08280
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
LVPFIGRTLGGLLARF
Physicochemical Analysis
C83H136N22O18
NDCEQHKMSWY
L
1730.13
12.40
2
0
9
+2
-2.67
1.175
146.25
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
4
L
0
K
0
M
2
F
1
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 4 K: 0 M: 0 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
16
C83H136N22O18
1730.13
12.40
+2
-2.67
1.175
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against S. aureus (MIC 4 uM) and E-coli (MIC >64 uM) evaluated using microdilution assay in MH medium.
Evidence 2 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus

Source & Reference

Antifungipept

Other

Active against S. aureus (MIC 4 uM) and E-coli (MIC >64 uM) evaluated using microdilution assay in MH medium.
Evidence 3 Activity

Activity

<20% Killing
Toxicity
100 µM
Cytotoxic
<20% Killing | 100 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Membrane-active antimicrobial peptide identified in Rana arvalis by targeted DNA sequencing. | Biochim Biophys Acta | 2018
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2019 Mar 1 1861(3):651-659.