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Peptide record

TPDB08278

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08278
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia CancerPPD 2.0 dbACP PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
CLNLKALLAVAKKILC
Physicochemical Analysis
C78H144N20O18S2
RDEQGHMFPSTWY
L
1714.24
9.80
3
0
10
+3
-0.64
1.431
183.12
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
7.29
3
Residue Composition
number
3
A
0
R
1
N
0
D
2
C
0
E
0
Q
0
G
0
H
1
I
5
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
16
C78H144N20O18S2
1714.24
9.80
+3
-0.64
1.431
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
39.53 µM
Cytotoxic
IC50 | 39.53 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering. | Int J Biol Sci | 2018
Evidence 2 Activity

Activity

50% hemolysis
Toxicity
9.19 µM
Hemolytic Cytotoxic
50% hemolysis | 9.19 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering. | Int J Biol Sci | 2018
Evidence 3 Activity

Activity

IC50
Toxicity
39.53 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29904274]50% hemolysis against horse erythrocytes at 9.19 µM. | Cytotoxicity: [Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=39.53 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Biol Sci. 2018 Apr 25 14(6):599-607.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis