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Peptide record

TPDB08266

Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08266
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
IKNAKVCVYAVCVSHK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C78H132N22O20S2
RDEQGLMFPTW
V
1762.16
9.63
4
0
8
+3
0.26
0.588
109.38
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1615
0.92
5
Residue Composition
number
2
A
0
R
1
N
0
D
2
C
0
E
0
Q
0
G
1
H
1
I
0
L
3
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 4
Chemical Descriptors
16 reviewed residue count
C78H132N22O20S2 sequence-only estimate (linear, free termini)
1762.16 sequence-only estimate (linear, free termini)
9.63 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.26 sequence-only estimate (linear, free termini)
0.588 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

55% Killing
Toxicity
32 µM
Cytotoxic
55% Killing | 32 | µM | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptides from the Arctic Polychaeta Nicomache minor Provide New Molecular Insight into Biological Role of the BRICHOS Domain. | Mar Drugs | 2018
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
50% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptides from the Arctic Polychaeta Nicomache minor Provide New Molecular Insight into Biological Role of the BRICHOS Domain. | Mar Drugs | 2018
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2018 Oct 23 16(11):401.