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Peptide record

TPDB08211

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08211
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 16-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RRLRPRRPRLPRPRPR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C91H167N43O17
ANDCEQGHIKMFSTWYV
R
2135.61
13.30
9
0
2
+9
7.78
-2.556
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
5
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 5 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C91H167N43O17 sequence-only estimate (linear, free termini)
2135.61 sequence-only estimate (linear, free termini)
13.30 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
7.78 sequence-only estimate (linear, free termini)
-2.556 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
>25 µM
Cytotoxic
IC50 | >25 | µM | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action. | Front Microbiol | 2018
Evidence 2 Activity

Activity

IC50
Toxicity
>25 µM
Cytotoxic
IC50 | >25 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action. | Front Microbiol | 2018