Back to search

Peptide record

TPDB08208

Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08208
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RFRRLRWKTRWRLKKI
Physicochemical Analysis
C107H179N39O18
ANDCEQGHMPSYV
R
2299.85
13.10
9
0
6
+9
1.71
-1.644
73.12
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
478.29
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
3
K
0
M
1
F
0
P
0
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C107H179N39O18
2299.85
13.10
+9
1.71
-1.644
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 4 uM), S. typhimurium 7731 (MIC 8 uM), S. aureus 29213 (MIC 4 uM), S. epidermidis 12228 (MIC 8
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. typhimurium 7731

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 4 uM), S. typhimurium 7731 (MIC 8 uM), S. aureus 29213 (MIC 4 uM), S. epidermidis 12228 (MIC 8 uM), S. faecalis 29212 (MIC 4 uM
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus 29213

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 4 uM), S. typhimurium 7731 (MIC 8 uM), S. aureus 29213 (MIC 4 uM), S. epidermidis 12228 (MIC 8 uM), S. faecalis 29212 (MIC 4 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus epidermidis 12228

Source & Reference

dbAMP DRAMP

Other

e against E. coli (MIC 4 uM), S. typhimurium 7731 (MIC 8 uM), S. aureus 29213 (MIC 4 uM), S. epidermidis 12228 (MIC 8 uM), S. faecalis 29212 (MIC 4 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. faecalis 29212

Source & Reference

dbAMP DRAMP

Other

typhimurium 7731 (MIC 8 uM), S. aureus 29213 (MIC 4 uM), S. epidermidis 12228 (MIC 8 uM), S. faecalis 29212 (MIC 4 uM).
Evidence 6 Activity

Activity

5% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of imperfectly amphipathic ?-helical antimicrobial peptides with enhanced cell selectivity. | Acta Biomater | 2014
Evidence 7 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ?-helical propensity. | Acta Biomater | 2015
Evidence 8 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25818457] 0 % hemolysis at 294.3 mg/L against human red blood cells | Cytotoxicity: [Ref.25818457] The cell viability of PRW4 is 100%, 96%, 92%, 86%, 85%, 83%, 82%, 80% and 80% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomaterials. 2015 Jun 52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.