TPDB

3D PDB MODEL

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TPDB ID TPDB08207

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

RFRRLRWKTRKRLWKI

FASTA

>TPDB08207|Antibacterial;Toxicity|length=16
RFRRLRWKTRKRLWKI

Formula C107H179N39O18

Absent Amino Acids ANDCEQGHMPSYV

Common Amino Acids R

Mass 2299.85

PI 13.10

Basic Residues 9

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +9

Boman Index 1.71

Hydrophobicity -1.644

Aliphatic Index 73.12

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 478.29

Polar Residues 1

number

0

A

6

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

2

L

3

K

0

M

1

F

0

P

0

S

1

T

2

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 0

Length

16

Formula

C107H179N39O18

Mass

2299.85

PI

13.10

Net Charge

+9

Boman Index

1.71

Hydrophobicity

-1.644

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 8-16 uM), S. typhimurium 7731 (MIC 16 uM), S. aureus 29213 (MIC 8 uM), S. epidermidis 12228 (MIC 3

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism S. typhimurium 7731

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 8-16 uM), S. typhimurium 7731 (MIC 16 uM), S. aureus 29213 (MIC 8 uM), S. epidermidis 12228 (MIC 32 uM), S. faecalis 29212 (MIC 8 u

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus 29213

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 8-16 uM), S. typhimurium 7731 (MIC 16 uM), S. aureus 29213 (MIC 8 uM), S. epidermidis 12228 (MIC 32 uM), S. faecalis 29212 (MIC 8 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µM

Target

Target Organism Staphylococcus epidermidis 12228

Source & Reference

Database Source NA

Other

Evidence Text

ainst E. coli (MIC 8-16 uM), S. typhimurium 7731 (MIC 16 uM), S. aureus 29213 (MIC 8 uM), S. epidermidis 12228 (MIC 32 uM), S. faecalis 29212 (MIC 8 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism S. faecalis 29212

Source & Reference

Database Source NA

Other

Evidence Text

phimurium 7731 (MIC 16 uM), S. aureus 29213 (MIC 8 uM), S. epidermidis 12228 (MIC 32 uM), S. faecalis 29212 (MIC 8 uM).

Evidence 6 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Design of imperfectly amphipathic ?-helical antimicrobial peptides with enhanced cell selectivity. | Acta Biomater | 2014