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Peptide record

TPDB08204

Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08204
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RFRRLRKKKRKRLKKI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C99H188N40O17
ANDCEQGHMPSTWYV
RK
2210.84
13.11
12
0
4
+12
6.57
-2.219
73.12
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
6
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C99H188N40O17 sequence-only estimate (linear, free termini)
2210.84 sequence-only estimate (linear, free termini)
13.11 sequence-only estimate (linear, free termini)
+12 sequence-only estimate (linear, free termini)
6.57 sequence-only estimate (linear, free termini)
-2.219 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
50% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide. | PLoS One | 2014
Evidence 2 Activity

Activity

HC50
Toxicity
256 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25494332] HC50>256 µM against human red blood cells | Cytotoxicity: [Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2014 Dec 10 9(12):e114605. doi: 10.1371/journal.pone.0114605.