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Peptide record

TPDB08204

Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08204
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RFRRLRKKKRKRLKKI
Physicochemical Analysis
C99H188N40O17
ANDCEQGHMPSTWYV
RK
2210.84
13.11
12
0
4
+12
8.24
-2.219
73.12
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
6
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C99H188N40O17
2210.84
13.11
+12
8.24
-2.219
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
50% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide. | PLoS One | 2014
Evidence 2 Activity

Activity

HC50
Toxicity
256 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25494332] HC50>256 µM against human red blood cells | Cytotoxicity: [Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2014 Dec 10 9(12):e114605. doi: 10.1371/journal.pone.0114605.