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Peptide record

TPDB08201

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08201
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RFRRLRDKTRDRLKKI
Physicochemical Analysis
C93H169N37O22
ANCEQGHMPSWYV
R
2157.60
12.41
9
2
4
+7
7.87
-1.969
73.12
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
2
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
3
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C93H169N37O22
2157.60
12.41
+7
7.87
-1.969
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ?-helical propensity. | Acta Biomater | 2015
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ?-helical propensity. | Acta Biomater | 2015
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25735802] MHC5>256 µM against human red blood cells | Cytotoxicity: [Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Acta Biomater. 2015 May 18:155-67. doi: 10.1016/j.actbio.2015.02.023.