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Peptide record

TPDB08198

Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08198
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
VKWRWKKWRWKWKWKV
Physicochemical Analysis
C124H176N34O17
ANDCEQGHILMFPSTY
KW
2414.98
12.46
8
0
8
+8
-3.40
-1.837
36.25
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
33000
1366.47
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 2
Chemical Descriptors
16
C124H176N34O17
2414.98
12.46
+8
-3.40
-1.837
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
178.3±11.5 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 178.3±11.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>320 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016
Evidence 3 Activity

Activity

18% Hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
18% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016