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Peptide record

TPDB08194

Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08194
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RFRRLRKKTRKRLKKI
Physicochemical Analysis
C97H183N39O18
ANDCEQGHMPSWYV
R
2183.77
13.11
11
0
4
+11
7.39
-2.019
73.12
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
5
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C97H183N39O18
2183.77
13.11
+11
7.39
-2.019
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
128 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S. epidermidis 12228 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.typhimurium 7731

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S. epidermidis 12228 (MIC 32 uM), S.faecalis 29212 (MIC 128
Evidence 3 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.aureus 29213

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S. epidermidis 12228 (MIC 32 uM), S.faecalis 29212 (MIC 128 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus epidermidis 12228

Source & Reference

dbAMP DRAMP

Other

ainst E. coli (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S. epidermidis 12228 (MIC 32 uM), S.faecalis 29212 (MIC 128 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.faecalis 29212

Source & Reference

dbAMP DRAMP

Other

imurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S. epidermidis 12228 (MIC 32 uM), S.faecalis 29212 (MIC 128 uM).
Evidence 6 Activity

Activity

5% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of imperfectly amphipathic ?-helical antimicrobial peptides with enhanced cell selectivity. | Acta Biomater | 2014
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
50% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide. | PLoS One | 2014
Evidence 8 Activity

Activity

HC50
Toxicity
256 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25494332] HC50>256 µM against human red blood cells | Cytotoxicity: [Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2014 Dec 10 9(12):e114605. doi: 10.1371/journal.pone.0114605.