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Peptide record

TPDB08192

LK‐1 Antibacterial Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08192
LK‐1
Antibacterial Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia dbAMP 3.0 CellPPD-MOD CPPsite3.0 MLCPP 2.0 PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antiviral, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LKKLLKLLKKLLKLAG
Physicochemical Analysis
C89H170N22O17
RNDCEQHIMFPSTWYV
L
1820.47
11.21
6
0
9
+6
1.30
0.525
201.25
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
8
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 8 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C89H170N22O17
1820.47
11.21
+6
1.30
0.525
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 8 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa and HEK 293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
TAMRA dye and Enhanced green fluorescence protein (eGFP)
Cytosol and Nucleus
Cell penetration order: Tat < LK‐1 < LK‐2 < LK‐dimer
Receptor‐mediated endocytosis and macropinocytosis
In vitro
CCCCCCCCC
Evidence 2 Activity

Activity

MHC10
Hemolysis
0.08 µM
[Ref.23894079] MHC10=0.08 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
0.63 µM
Hemolytic Cytotoxic
10% Hemolysis | 0.63 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Reduction of helical content by insertion of a disulfide bond leads to an antimicrobial peptide with decreased hemolytic activity. | ChemMedChem | 2013
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
0.31 µM
Hemolytic Cytotoxic
10% Hemolysis | 0.31 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Reduction of helical content by insertion of a disulfide bond leads to an antimicrobial peptide with decreased hemolytic activity. | ChemMedChem | 2013
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
0.16 µM
Hemolytic Cytotoxic
10% Hemolysis | 0.16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Reduction of helical content by insertion of a disulfide bond leads to an antimicrobial peptide with decreased hemolytic activity. | ChemMedChem | 2013
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
0.08 µM
Hemolytic Cytotoxic
10% Hemolysis | 0.08 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Reduction of helical content by insertion of a disulfide bond leads to an antimicrobial peptide with decreased hemolytic activity. | ChemMedChem | 2013
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23894079] MHC10=0.08 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.
Evidence 8 Hemolysis

Activity

0.08 µM
MHC10
[Ref.23894079] MHC10=0.08 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.
DRAMP4
PD_Hemolysis
Additional Detail Fields 1 fields
CCCCCCCCC