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Peptide record

TPDB08182

Antibacterial Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08182
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
CKKLLKLLKKLCKLAG
Physicochemical Analysis
C83H158N22O17S2
RNDEQHIMFPSTWYV
LK
1800.42
10.54
6
0
7
+6
1.94
0.362
152.50
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
6.94
2
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
6
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C83H158N22O17S2
1800.42
10.54
+6
1.94
0.362
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
0.31 µM
Hemolytic Cytotoxic
10% Hemolysis | 0.31 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Reduction of helical content by insertion of a disulfide bond leads to an antimicrobial peptide with decreased hemolytic activity. | ChemMedChem | 2013
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
2.5 µM
Hemolytic Cytotoxic
10% Hemolysis | 2.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Reduction of helical content by insertion of a disulfide bond leads to an antimicrobial peptide with decreased hemolytic activity. | ChemMedChem | 2013
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis