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Peptide record

TPDB08181

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08181
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RPAFRKAAFRVMRACV
Physicochemical Analysis
C83H139N29O17S2
NDEQGHILSTWY
AR
1879.32
12.41
5
0
9
+5
1.41
0.131
61.25
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
4
A
4
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
1
M
2
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 4 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 1 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
16
C83H139N29O17S2
1879.32
12.41
+5
1.41
0.131
Evidence Records 3 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 80 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides. | J Biol Chem | 2008
Evidence 2 Activity

Activity

6% Hemolysis
Toxicity
2500 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 2500 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides. | J Biol Chem | 2008
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011