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Peptide record

TPDB08175

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08175
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 16-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGGLIKKWPWWPWRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C109H152N28O17
ANDCEQHMSTYV
W
2126.58
12.42
4
0
8
+4
0.75
-0.594
73.12
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
22000
10.35
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
2
K
0
M
1
F
2
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 2 M: 0 F: 1 P: 2 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C109H152N28O17 sequence-only estimate (linear, free termini)
2126.58 sequence-only estimate (linear, free termini)
12.42 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.75 sequence-only estimate (linear, free termini)
-0.594 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

40% hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
40% hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
15.62 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 15.62 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 4 Activity

Activity

50% Cell death
Toxicity
90 µg/mL
Cytotoxic
50% Cell death | 90 | µg/mL | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26046345] The hemolytic activities of RN7-IN7 is 0.0% at 15.62µg/ml against human RBCs. | Cytotoxicity: [Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 31.25 µg/ml. The cell viability of NL-20 is 51%, 13% and 7% at peptide concentrations of 62.5, 125 and 250 µg/ml.## The cell viability of WRL-68 cell line is not affected

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2015 Jun 5 10(6):e0128532.