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Peptide record

TPDB08150

Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08150
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GKLSSLWKKLKKIIAK
Physicochemical Analysis
C88H157N23O19
RNDCEQHMFPTYV
K
1841.36
11.21
6
0
7
+6
1.89
-0.256
128.12
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
298.69
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
3
L
6
K
0
M
0
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 6 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
16
C88H157N23O19
1841.36
11.21
+6
1.89
-0.256
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>400 µM
Hemolytic Cytotoxic
50% Hemolysis | >400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. | J Nat Prod | 2016
Evidence 2 Activity

Activity

LC50
Toxicity
400 µM
Hemolytic
Hemolytic_activity: [Ref.26998557] LC50>400 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 2016 Apr 22 79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.