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Peptide record

TPDB08143

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08143
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 16-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
NWKKIASIGKEVLKAL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C84H144N22O21
RDCQHMFPTY
K
1798.20
10.55
4
1
8
+3
0.53
-0.019
128.12
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5500
3.06
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
1
G
0
H
2
I
2
L
4
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
16 reviewed residue count
C84H144N22O21 sequence-only estimate (linear, free termini)
1798.20 sequence-only estimate (linear, free termini)
10.55 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.53 sequence-only estimate (linear, free termini)
-0.019 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs | Peptides | 2008