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Peptide record

TPDB08142

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08142
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPIVGKLLSGLSGLL
Physicochemical Analysis
C79H135N17O19
ARNDCEQHMTWY
L
1627.04
10.10
1
0
9
+1
-3.00
1.625
188.75
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
6
L
1
K
0
M
1
F
1
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 6 K: 1 M: 0 F: 1 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
16
C79H135N17O19
1627.04
10.10
+1
-3.00
1.625
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml)
Evidence 2 Activity

Activity

MIC
Antibacterial
1.5-3.0 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
6.5 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

am+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml)
Evidence 5 Activity

Activity

MIC
Antifungal
1.5-3.0 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
6.5 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

am+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml).
Evidence 7 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml)
Evidence 8 Activity

Activity

MIC
Antiparasitic
1.5-3.0 µg/mL

Target

B. dysenteriae

Source & Reference

DRAMP

Other

Active against Gram+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
6.5 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

am+ S. aureus (MIC 2 ug/ml), Gram- E. coli, B. dysenteriae (MIC 1.5-3.0 ug/ml), and fungi C. albicans (MIC 6.5 ug/ml).
Evidence 10 Activity

Activity

25% Hemolysis
Toxicity
61.46 µM
Hemolytic Cytotoxic
25% Hemolysis | 61.46 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells | Int J Pept Res Ther | 2014
Evidence 11 Activity

Activity

87% Degranulation
Toxicity
100 µg/mL
Cytotoxic
87% Degranulation | 100 | µg/mL | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis | Peptides | 2006
Evidence 12 Activity

Activity

IC50
Toxicity
77
Cytotoxic
Cytotoxicity: [Ref.17000029]Display cytotoxicity against HepG2(IC50=77 mg/ml).

Source & Reference

NA
DRAMP
Peptides. 2006 Dec 27(12):3085-3091.