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Peptide record

TPDB08131

Antibacterial Anticancer Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08131
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RIHPPPFYPPFRRFL
Physicochemical Analysis
C97H138N26O17
ANDCEQGKMSTWV
P
1940.33
12.11
4
0
6
+3
0.44
-0.620
52.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
76.79
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
1
L
0
K
0
M
3
F
5
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 0 M: 0 F: 3 P: 5 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C97H138N26O17
1940.33
12.11
+3
0.44
-0.620
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
43.3±7.7 µM
Cytotoxic
50% Cytotoxicity | 43.3±7.7 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
43.3
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <5% Hemolysis=64 µM | Cytotoxicity: Human PBMC: IC50=43.3 ± 7.7 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Cell Infect Microbiol. 2020 Oct 19 10:552905.