Back to search

Peptide record

TPDB08128

Antibacterial Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08128
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IWRIFRRIFRIFIRF
Physicochemical Analysis
C107H163N31O16
ANDCEQGHLKMPSTYV
RI
2139.67
13.00
5
0
10
+5
-3.87
0.687
130.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
257.05
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
5
I
0
L
0
K
0
M
4
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 5 L: 0 K: 0 M: 0 F: 4 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
15
C107H163N31O16
2139.67
13.00
+5
-3.87
0.687
Evidence Records 4 records
Evidence 1 Activity

Activity

MHC
Hemolysis
15.0 µM
[Ref.22699557]MHC=15.0 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Amino Acids. 2012 Dec 43(6):2527-36. doi: 10.1007/s00726-012-1334-7.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
15.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 15.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biochemical property and membrane-peptide interactions of de novo antimicrobial peptides designed by helix-forming units. | Amino Acids | 2012
Evidence 3 Activity

Activity

MHC
Toxicity
15.0 µM
Hemolytic
Hemolytic_activity: [Ref.22699557]MHC=15.0 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2012 Dec 43(6):2527-36. doi: 10.1007/s00726-012-1334-7.
Evidence 4 Hemolysis

Activity

15.0 µM
MHC
[Ref.22699557]MHC=15.0 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Amino Acids. 2012 Dec 43(6):2527-36. doi: 10.1007/s00726-012-1334-7.
DRAMP4
PD_Hemolysis