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Peptide record

TPDB08117

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08117
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RVRRFPWWWPFLRRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C108H156N36O16
ANDCEQGHIKMSTY
R
2214.66
13.10
6
0
7
+6
4.51
-1.287
45.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
7.45
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
2
F
2
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 2 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
15 reviewed residue count
C108H156N36O16 sequence-only estimate (linear, free termini)
2214.66 sequence-only estimate (linear, free termini)
13.10 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.51 sequence-only estimate (linear, free termini)
-1.287 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Escherichia coli KCTC 1682

Source & Reference

NA

Other

Active against E. coli KCTC 1682 (MIC 16 ug/ml), S. typhimurium KCTC 1926 (MIC 16 ug/ml), B. subtilis KCTC 3068 (MIC 4 ug/ml), and S. aur
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

S. typhimurium KCTC 1926

Source & Reference

NA

Other

Active against E. coli KCTC 1682 (MIC 16 ug/ml), S. typhimurium KCTC 1926 (MIC 16 ug/ml), B. subtilis KCTC 3068 (MIC 4 ug/ml), and S. aureus KCTC 1621 (MIC 8 ug/ml). Nonstandard
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

B. subtilis KCTC 3068

Source & Reference

NA

Other

Active against E. coli KCTC 1682 (MIC 16 ug/ml), S. typhimurium KCTC 1926 (MIC 16 ug/ml), B. subtilis KCTC 3068 (MIC 4 ug/ml), and S. aureus KCTC 1621 (MIC 8 ug/ml). Nonstandard assays in 50% LB.
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus KCTC 1621

Source & Reference

NA

Other

ug/ml), S. typhimurium KCTC 1926 (MIC 16 ug/ml), B. subtilis KCTC 3068 (MIC 4 ug/ml), and S. aureus KCTC 1621 (MIC 8 ug/ml). Nonstandard assays in 50% LB.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
60.9 µM
Hemolytic Cytotoxic
50% Hemolysis | 60.9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of perfectly symmetric Trp-rich peptides with potent and broad-spectrum antimicrobial activities. | Int J Antimicrob Agents | 2006