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Peptide record

TPDB08101

Antibacterial Anticancer Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08101
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia CancerPPD 2.0 CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FKKLKKLFSKLWNWK
Physicochemical Analysis
C101H156N24O18
ARDCEQGHIMPTYV
K
1994.50
11.21
6
0
7
+6
-1.15
-0.833
78.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
551.52
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
6
K
0
M
2
F
0
P
1
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 6 M: 0 F: 2 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C101H156N24O18
1994.50
11.21
+6
-1.15
-0.833
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram- E. coli ATCC 25922 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aure
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

active against Gram- E. coli ATCC 25922 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermi
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

active against Gram- E. coli ATCC 25922 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 1 uM), S. pneumoni
Evidence 4 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

C 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 1 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP

Other

(MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 1 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP

Other

(MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 1 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
1 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram- E. coli ATCC 25922 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aure
Evidence 8 Activity

Activity

MIC
Antifungal
2 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb

Other

active against Gram- E. coli ATCC 25922 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermi
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb

Other

active against Gram- E. coli ATCC 25922 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 1 uM), S. pneumoni
Evidence 10 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb

Other

C 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 1 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 11 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP CAFPdb

Other

(MIC 2 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 1 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
2 µM

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP CAFPdb

Other

(MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 1 uM), S. epidermidis ATCC 12228 (MIC 1 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 13 Activity

Activity

5% Hemolysis
Toxicity
64±6.80 µM
Hemolytic Cytotoxic
5% Hemolysis | 64±6.80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
TAT Modification of Alpha-Helical Anticancer Peptides to Improve Specificity and Efficacy. | PLoS One | 2015
Evidence 14 Activity

Activity

MHC
Toxicity
64
Hemolytic Cytotoxic
Hemolytic_activity: Human RBC: MHC=64±6.80 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2015 Sep 25 10(9):e0138911.
Evidence 15 Activity

Activity

MHC
Toxicity
32 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells: MHC=32 µM, MHC: the minimum hemolytic concentration is the concentration of peptide that results in 10% hemolysis of human red blood cells (hRBCs). | Cytotoxicity: HUVEC: IC50=24.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Pharm. 2019 Feb 4 16(2):561-572.