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Peptide record

TPDB08075

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard

15 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08075

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

TSRCYIGYRRKVVCS

FASTA

>TPDB08075|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=15
TSRCYIGYRRKVVCS

Formula C76H127N25O21S2

Absent Amino Acids ANDEQHLMFPW

Common Amino Acids R

Mass 1791.12

PI 10.09

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +4

Boman Index 1.30

Hydrophobicity -0.320

Aliphatic Index 64.67

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 3105

Absorbance 280nm 173.36

Polar Residues 7

number

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 2 V: 2

Length

Formula

C76H127N25O21S2

Mass

1791.12

10.09

Net Charge

Boman Index

1.30

Hydrophobicity

-0.320

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 17.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 35 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 17.5 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

nst E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 17.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 35 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 17.5 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

nst E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 17.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 35 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 17.5 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

nst E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 17.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 35 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 17.5 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8.8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

nst E. coli (MIC 17.5 ug/ml), S. aureus (MIC 35 ug/ml), B. subtilis (MIC 17.5 ug/ml), and C. albicans (MIC 8.8 ug/ml). Aslo histamine release.

Evidence 17 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 18 Activity

Activity

Activity Endpoint (11.3±1.7)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(11.3±1.7)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007