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Peptide record

TPDB08073

Antibacterial Anticancer Antifungal Antiviral Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08073
Antibacterial Anticancer Antifungal Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb AI4AVP
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FKCRRWQWRMKKLGA
Physicochemical Analysis
C91H144N30O17S2
NDEHIPSTYV
RK
1994.46
12.14
6
0
6
+6
-0.04
-1.207
32.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
551.53
2
Residue Composition
number
1
A
3
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
1
L
3
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C91H144N30O17S2
1994.46
12.14
+6
-0.04
-1.207
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Comparative antimicrobial activity and mechanism of action of bovine lactoferricin-derived synthetic peptides. | Biometals | 2011
Evidence 2 Activity

Activity

8% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Killing of Staphylococcus aureus and Salmonella enteritidis and neutralization of lipopolysaccharide by 17-residue bovine lactoferricins: improved activity of Trp/Ala-containing molecules. | Sci Rep | 2017
Evidence 3 Activity

Activity

7.9% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
7.9% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens. | Biomed Res Int | 2018