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Peptide record

TPDB08072

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08072
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb i2APP ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VNWKKVLGKIIKVAK
Physicochemical Analysis
C83H146N22O17
RDCEQHMFPSTY
K
1724.21
11.12
5
0
8
+5
2.39
0.193
142.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
318.99
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
1
L
5
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
15
C83H146N22O17
1724.21
11.12
+5
2.39
0.193
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
14.3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
15.8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
1.7 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

ainst B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
0.8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
14.3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
15.8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
1.7 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.8 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 10 Activity

Activity

MIC
Antiparasitic
14.3 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
15.8 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 12 Activity

Activity

MIC
Antiparasitic
1.7 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

ainst B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 13 Activity

Activity

MIC
Antiviral
0.8 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 14 Activity

Activity

MIC
Antiviral
14.3 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 15 Activity

Activity

MIC
Antiviral
15.8 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 16 Activity

Activity

MIC
Antiviral
1.7 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

ainst B. subtilis (MIC 0.8 uM), S. aureus (MIC 14.3 uM), P. aeruginosa (MIC 15.8 uM), and E. coli (MIC 1.7 uM).
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). | Chembiochem | 2009
Evidence 18 Activity

Activity

<5% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 512 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Impact of lipidation site on the activity of α-helical antimicrobial peptides | Bioorg Chem | 2024
Evidence 19 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Impact of lipidation site on the activity of α-helical antimicrobial peptides | Bioorg Chem | 2024
Evidence 20 Activity

Activity

IC50
Toxicity
8.07 µg/mL
Cytotoxic
IC50 | 8.07 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Lipidation of Naturally Occurring α-Helical Antimicrobial Peptides as a Promising Strategy for Drug Design | Int J Mol Sci | 2023
Evidence 21 Activity

Activity

IC50
Toxicity
10.10 µg/mL
Cytotoxic
IC50 | 10.10 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Lipidation of Naturally Occurring α-Helical Antimicrobial Peptides as a Promising Strategy for Drug Design | Int J Mol Sci | 2023
Evidence 22 Activity

Activity

LC50
Toxicity
200 µM
Hemolytic
Hemolytic_activity: [Ref.19591185]LC50>200 µM against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2009 Aug 17 10(12):2089-2099.