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Peptide record

TPDB08069

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08069
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LNLKGIFKKVASLLT
Physicochemical Analysis
C78H137N19O19
RDCEQHMPWY
L
1645.06
10.84
3
0
8
+3
-0.11
0.760
156.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
4
L
3
K
0
M
1
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C78H137N19O19
1645.06
10.84
+3
-0.11
0.760
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ S-aureus ATCC 6538 (MIC >60 uM), S. aureus ATCC 25923 (MIC 6 uM), S. saprophytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (
Evidence 2 Activity

Activity

MIC
Antibacterial
60 µM

Target

B. subtilis CCT 2471

Source & Reference

dbAMP DRAMP

Other

ATCC 25923 (MIC 6 uM), S. saprophytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922
Evidence 3 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli CCT 1371

Source & Reference

dbAMP DRAMP

Other

ytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922 (MIC 6 uM), E-cloacae ATCC 2
Evidence 4 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

T 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922 (MIC 6 uM), E-cloacae ATCC 23355 (MIC>60 uM), P-mirabilis ((MIC > 60 uM), and P. aeruginosa ATCC 154
Evidence 5 Activity

Activity

MIC
Antibacterial
30 µM

Target

Pseudomonas aeruginosa ATCC 15442

Source & Reference

dbAMP DRAMP

Other

ATCC 25922 (MIC 6 uM), E-cloacae ATCC 23355 (MIC>60 uM), P-mirabilis ((MIC > 60 uM), and P. aeruginosa ATCC 15442 (MIC 30 uM) (ref. see AP1640). This mast cell degranulating peptide moderately stimulated degranulati
Evidence 6 Activity

Activity

MIC
Antifungal
6 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ S-aureus ATCC 6538 (MIC >60 uM), S. aureus ATCC 25923 (MIC 6 uM), S. saprophytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (
Evidence 7 Activity

Activity

MIC
Antifungal
60 µM

Target

B. subtilis CCT 2471

Source & Reference

dbAMP DRAMP Antifungipept

Other

ATCC 25923 (MIC 6 uM), S. saprophytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922
Evidence 8 Activity

Activity

MIC
Antifungal
6 µM

Target

Escherichia coli CCT 1371

Source & Reference

dbAMP DRAMP Antifungipept

Other

ytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922 (MIC 6 uM), E-cloacae ATCC 2
Evidence 9 Activity

Activity

MIC
Antifungal
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

T 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922 (MIC 6 uM), E-cloacae ATCC 23355 (MIC>60 uM), P-mirabilis ((MIC > 60 uM), and P. aeruginosa ATCC 154
Evidence 10 Activity

Activity

MIC
Antifungal
30 µM

Target

Pseudomonas aeruginosa ATCC 15442

Source & Reference

dbAMP DRAMP Antifungipept

Other

ATCC 25922 (MIC 6 uM), E-cloacae ATCC 23355 (MIC>60 uM), P-mirabilis ((MIC > 60 uM), and P. aeruginosa ATCC 15442 (MIC 30 uM) (ref. see AP1640). This mast cell degranulating peptide moderately stimulated degranulati
Evidence 11 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ S-aureus ATCC 6538 (MIC >60 uM), S. aureus ATCC 25923 (MIC 6 uM), S. saprophytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (
Evidence 12 Activity

Activity

MIC
Antiparasitic
60 µM

Target

B. subtilis CCT 2471

Source & Reference

DRAMP

Other

ATCC 25923 (MIC 6 uM), S. saprophytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922
Evidence 13 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Escherichia coli CCT 1371

Source & Reference

DRAMP

Other

ytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922 (MIC 6 uM), E-cloacae ATCC 2
Evidence 14 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

T 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922 (MIC 6 uM), E-cloacae ATCC 23355 (MIC>60 uM), P-mirabilis ((MIC > 60 uM), and P. aeruginosa ATCC 154
Evidence 15 Activity

Activity

MIC
Antiparasitic
30 µM

Target

Pseudomonas aeruginosa ATCC 15442

Source & Reference

DRAMP

Other

ATCC 25922 (MIC 6 uM), E-cloacae ATCC 23355 (MIC>60 uM), P-mirabilis ((MIC > 60 uM), and P. aeruginosa ATCC 15442 (MIC 30 uM) (ref. see AP1640). This mast cell degranulating peptide moderately stimulated degranulati
Evidence 16 Activity

Activity

MIC
Antiviral
6 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram+ S-aureus ATCC 6538 (MIC >60 uM), S. aureus ATCC 25923 (MIC 6 uM), S. saprophytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (
Evidence 17 Activity

Activity

MIC
Antiviral
60 µM

Target

B. subtilis CCT 2471

Source & Reference

DRAMP

Other

ATCC 25923 (MIC 6 uM), S. saprophytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922
Evidence 18 Activity

Activity

MIC
Antiviral
6 µM

Target

Escherichia coli CCT 1371

Source & Reference

DRAMP

Other

ytius (CS) (MIC 6 uM), S-epidermius (CS) (MIC > 60 uM), B. subtilis CCT 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922 (MIC 6 uM), E-cloacae ATCC 2
Evidence 19 Activity

Activity

MIC
Antiviral
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

T 2471 (MIC 60 uM), E. coli CCT 1371 (MIC 6 uM), B-thuringiensis (WT) (MIC >60 uM), Gram- E. coli ATCC 25922 (MIC 6 uM), E-cloacae ATCC 23355 (MIC>60 uM), P-mirabilis ((MIC > 60 uM), and P. aeruginosa ATCC 154
Evidence 20 Activity

Activity

MIC
Antiviral
30 µM

Target

Pseudomonas aeruginosa ATCC 15442

Source & Reference

DRAMP

Other

ATCC 25922 (MIC 6 uM), E-cloacae ATCC 23355 (MIC>60 uM), P-mirabilis ((MIC > 60 uM), and P. aeruginosa ATCC 15442 (MIC 30 uM) (ref. see AP1640). This mast cell degranulating peptide moderately stimulated degranulati
Evidence 21 Activity

Activity

20% Hemolysis
Toxicity
1000 µM
Hemolytic Cytotoxic
20% Hemolysis | 1000 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus. | Peptides | 2006
Evidence 22 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.16762455]Non-hemolytic activity against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2006 Nov 27(11):2624-2631.##Toxicon. 2008 Apr 51(5):736-745.
Evidence 23 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.