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Peptide record

TPDB08063

Antibacterial Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08063
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AKRLKKLAKKIWKWL
Physicochemical Analysis
C94H160N26O16
NDCEQGHMFPSTYV
K
1910.47
11.90
7
0
8
+7
0.72
-0.680
117.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
575.77
0
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
6
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C94H160N26O16
1910.47
11.90
+7
0.72
-0.680
Evidence Records 2 records
Evidence 1 Activity

Activity

21% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
21% Hemolysis | 250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. | Biochim Biophys Acta | 2013
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
20.9 %
Hemolytic
Hemolytic_activity: [Ref.22982494] 20.9% hemolysis at 250 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Feb 1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005