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Peptide record

TPDB08057

Antibacterial Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08057
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AKRLKKLFKKIWNWK
Physicochemical Analysis
C98H159N27O17
DCEQGHMPSTYV
K
1987.51
11.90
7
0
7
+7
0.74
-1.100
84.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
553.46
1
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
6
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C98H159N27O17
1987.51
11.90
+7
0.74
-1.100
Evidence Records 2 records
Evidence 1 Activity

Activity

7% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
7% Hemolysis | 250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. | Biochim Biophys Acta | 2013
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
7.1 %
Hemolytic
Hemolytic_activity: [Ref.22982494] 7.1% hemolysis at 250 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Feb 1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005