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Peptide record

TPDB08056

Antibacterial Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08056
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AKRLKKLAKKIWKWK
Physicochemical Analysis
C94H161N27O16
NDCEQGHMFPSTYV
K
1925.48
11.93
8
0
7
+8
2.27
-1.193
91.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
571.29
0
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
7
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C94H161N27O16
1925.48
11.93
+8
2.27
-1.193
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 4 uM) and S. aureus (MIC 32 uM) in MHB.
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 4 uM) and S. aureus (MIC 32 uM) in MHB.
Evidence 3 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli (MIC 4 uM) and S. aureus (MIC 32 uM) in MHB.
Evidence 4 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 4 uM) and S. aureus (MIC 32 uM) in MHB.
Evidence 5 Activity

Activity

0% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
0% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 6 Activity

Activity

0% Hemolysis
Toxicity
15.625-62.5 µM
Hemolytic Cytotoxic
0% Hemolysis | 15.625-62.5 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance | Int J Mol Sci | 2020
Evidence 7 Activity

Activity

0.2% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
0.2% Hemolysis | 125 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance | Int J Mol Sci | 2020
Evidence 8 Activity

Activity

0.3% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
0.3% Hemolysis | 250 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance | Int J Mol Sci | 2020
Evidence 9 Activity

Activity

0% Cytotoxicity
Toxicity
15.625-62.5 µM
Cytotoxic
0% Cytotoxicity | 15.625-62.5 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance | Int J Mol Sci | 2020
Evidence 10 Activity

Activity

6.1% Cytotoxicity
Toxicity
125 µM
Cytotoxic
6.1% Cytotoxicity | 125 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance | Int J Mol Sci | 2020
Evidence 11 Activity

Activity

11.7% Cytotoxicity
Toxicity
250 µM
Cytotoxic
11.7% Cytotoxicity | 250 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance | Int J Mol Sci | 2020
Evidence 12 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.22982494] 0% hemolysis at 250 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Feb 1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005##Int J Mol Sci. 2020 Aug 6 21(16):5632. doi: 10.3390/ijms21165632