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Peptide record

TPDB08052

Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

15 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08052

Activity

Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides

Database_Source

Peptipedia AntiBP3 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, AntiCP 2.0, and other sources, with an available 3D structural model.

Sequence

FVDLKKIANIINSIF

FASTA

>TPDB08052|Anti-inflammatory;Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=15
FVDLKKIANIINSIF

Formula C83H135N19O21

Absent Amino Acids RCEQGHMPTWY

Common Amino Acids I

Mass 1735.10

PI 9.88

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +1

Boman Index 0.02

Hydrophobicity 0.953

Aliphatic Index 156.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 1 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 1 K: 2 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C83H135N19O21

Mass

1735.10

9.88

Net Charge

Boman Index

0.02

Hydrophobicity

0.953

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 14.4 µM

Target

Target Organism S. lactis

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus, B. cereus, S. lactis (MIC 14.4 uM). Active against plant pathogens Gram- E. amylovora (MIC 25-50 uM), X. arboricola pv. prun

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25-50 µM

Target

Target Organism E. amylovora

Source & Reference

Database Source NA

Other

Evidence Text

ainst S. aureus, B. cereus, S. lactis (MIC 14.4 uM). Active against plant pathogens Gram- E. amylovora (MIC 25-50 uM), X. arboricola pv. pruni and X. axonopodis pv. vesicatoria (MIC 3.1-6.2 uM) ( Camó C et a

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1-6.2 µM

Target

Target Organism v. vesicatoria

Source & Reference

Database Source NA

Other

Evidence Text

t pathogens Gram- E. amylovora (MIC 25-50 uM), X. arboricola pv. pruni and X. axonopodis pv. vesicatoria (MIC 3.1-6.2 uM) ( Camó C et al. 2018 ). Anticancer: LDH release: MCF-7 (IC50 40.18-49.09 uM incubation 10

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 14.4 µM

Target

Target Organism S. lactis

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against S. aureus, B. cereus, S. lactis (MIC 14.4 uM). Active against plant pathogens Gram- E. amylovora (MIC 25-50 uM), X. arboricola pv. prun

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25-50 µM

Target

Target Organism E. amylovora

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1-6.2 µM

Target

Target Organism v. vesicatoria

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 14.4 µM

Target

Target Organism S. lactis

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus, B. cereus, S. lactis (MIC 14.4 uM). Active against plant pathogens Gram- E. amylovora (MIC 25-50 uM), X. arboricola pv. prun

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25-50 µM

Target

Target Organism E. amylovora

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.1-6.2 µM

Target

Target Organism v. vesicatoria

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 14.4 µM

Target

Target Organism S. lactis

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus, B. cereus, S. lactis (MIC 14.4 uM). Active against plant pathogens Gram- E. amylovora (MIC 25-50 uM), X. arboricola pv. prun

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25-50 µM

Target

Target Organism E. amylovora

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.1-6.2 µM

Target

Target Organism v. vesicatoria

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 13 Activity

Activity

Detail Source Activity Hemolysis

Hemolysis Raw

Human erythrocytes: LD50=230 µM

Target

RBC Target Human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Zoolog Sci. 2009 Mar 26(3):220-6.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 230 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 230 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis. | Zoolog Sci | 2009

Evidence 15 Activity

Activity

Activity Endpoint LD50

Detail Source Activity Toxicity

Activity Measurement 230 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: LD50=230 µM | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Zoolog Sci. 2009 Mar 26(3):220-6.

Evidence 16 Hemolysis

Activity

Hemolysis Raw

Human erythrocytes: LD50=230 µM

Detail Source Activity Hemolysis

Target

RBC Target Human erythrocytes

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Zoolog Sci. 2009 Mar 26(3):220-6.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.