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Peptide record

TPDB08038

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08038
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VNSKKISGKSIKVSK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C70H131N21O21
ARDCEQHLMFPTWY
K
1602.94
11.12
5
0
4
+5
1.94
-0.613
90.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
0
L
5
K
0
M
0
F
0
P
4
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 5 M: 0 F: 0 P: 0 S: 4 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
15 reviewed residue count
C70H131N21O21 sequence-only estimate (linear, free termini)
1602.94 sequence-only estimate (linear, free termini)
11.12 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
1.94 sequence-only estimate (linear, free termini)
-0.613 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

LC50
Toxicity
100 µM
Hemolytic
Hemolytic_activity: [Ref.22526241]LC50>100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2012 Nov 43(5):2047-58.