TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08037

Activity

Antibacterial Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia HemoPI Hemolytic2

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

VNRKKILGKSIKVVK

FASTA

>TPDB08037|Antibacterial;Hemolysis;Toxicity|length=15
VNRKKILGKSIKVVK

Formula C78H148N24O18

Absent Amino Acids ADCEQHMFPTWY

Common Amino Acids K

Mass 1710.18

PI 11.85

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +6

Boman Index 5.35

Hydrophobicity -0.220

Aliphatic Index 136.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

1

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

2

I

1

L

5

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 5 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3

Length

15

Formula

C78H148N24O18

Mass

1710.18

PI

11.85

Net Charge

+6

Boman Index

5.35

Hydrophobicity

-0.220

Evidence 1 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Hemolysis

Activity Measurement 100 µM

Hemolysis Raw

[Ref.22526241]LC50=100 µM against human red blood cells

Target

RBC Target human red blood cells

Source & Reference

Database Source NA

Source DRAMP4

Reference

Amino Acids. 2012 Nov 43(5):2047-58.

Evidence 2 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Hemolysis

Activity Measurement 100 µM

Hemolysis Raw

[Ref.22526241]LC50>100 µM against human red blood cells

Target

RBC Target human red blood cells

Source & Reference

Database Source NA

Source DRAMP4

Reference

Amino Acids. 2012 Nov 43(5):2047-58.

Evidence 3 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.22526241]LC50=100 µM against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Amino Acids. 2012 Nov 43(5):2047-58.

Evidence 4 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.22526241]LC50>100 µM against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Amino Acids. 2012 Nov 43(5):2047-58.

Evidence 5 Hemolysis

Activity

Activity Measurement 100 µM

Activity Endpoint LC50

Hemolysis Raw

[Ref.22526241]LC50=100 µM against human red blood cells

Detail Source Activity Hemolysis

Target

RBC Target human red blood cells

Source & Reference

source HemoPI

Reference

Amino Acids. 2012 Nov 43(5):2047-58.

Source DRAMP4

Database Source NA

Evidence 6 Hemolysis

Activity

Activity Measurement 100 µM

Activity Endpoint LC50

Hemolysis Raw

[Ref.22526241]LC50>100 µM against human red blood cells

Detail Source Activity Hemolysis

Target

RBC Target human red blood cells

Source & Reference

source HemoPI

Reference

Amino Acids. 2012 Nov 43(5):2047-58.

Source DRAMP4

Database Source NA