Back to search

Peptide record

TPDB08029

Antibacterial Anticancer Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08029
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KKLLPIVANLLKSLL
Physicochemical Analysis
C80H147N19O18
RDCEQGHMFTWY
L
1663.16
10.84
3
0
9
+3
0.20
1.047
208.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
6
L
3
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 6 K: 3 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C80H147N19O18
1663.16
10.84
+3
0.20
1.047
Evidence Records 3 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
24 µM
Hemolytic Cytotoxic
<10% Hemolysis | 24 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide. | Front Chem | 2017
Evidence 2 Activity

Activity

IC50
Toxicity
49 µM
Cytotoxic
IC50 | 49 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide. | Front Chem | 2017
Evidence 3 Activity

Activity

IC50
Toxicity
49 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28443279] 11% hemolysis at 48µM, 55% hemolysis at 96µM against human red cells | Cytotoxicity: [Ref.28443279] IC50 = 49 µM against PBMCs. ##IC50 = 16 µM against A549 cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Chem. 2017 Apr 11 5:24