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Peptide record

TPDB08026

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08026
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, and Peptipedia, with an available 3D structural model.
Sequence
GLPALISWIKRKRQQ
Physicochemical Analysis
C82H140N26O19
NDCEHMFTYV
RQILK
1794.18
12.42
4
0
6
+4
1.59
-0.607
110.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
306.55
3
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
2
Q
1
G
0
H
2
I
2
L
2
K
0
M
0
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 2 L: 2 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
15
C82H140N26O19
1794.18
12.42
+4
1.59
-0.607
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
35-45 µg/mL

Target

Escherichia coli W 160-37

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli W 160-37 (MIC 35-45 ug/ml), S. aureus 8530B (MIC 25-35 ug/ml), B. subtilis (MIC 15-25 ug/ml), and P.putida NCIM 2102
Evidence 2 Activity

Activity

MIC
Antibacterial
25-35 µg/mL

Target

Staphylococcus aureus 8530B

Source & Reference

dbAMP

Other

Active against E. coli W 160-37 (MIC 35-45 ug/ml), S. aureus 8530B (MIC 25-35 ug/ml), B. subtilis (MIC 15-25 ug/ml), and P.putida NCIM 2102 (MIC >200 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
15-25 µg/mL

Target

B. subtilis

Source & Reference

dbAMP

Other

Active against E. coli W 160-37 (MIC 35-45 ug/ml), S. aureus 8530B (MIC 25-35 ug/ml), B. subtilis (MIC 15-25 ug/ml), and P.putida NCIM 2102 (MIC >200 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

P.putida NCIM 2102

Source & Reference

dbAMP

Other

(MIC 35-45 ug/ml), S. aureus 8530B (MIC 25-35 ug/ml), B. subtilis (MIC 15-25 ug/ml), and P.putida NCIM 2102 (MIC >200 ug/ml).
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
4500 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 4500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Individual substitution analogs of Mel(12-26), melittin's C-terminal 15-residue peptide: their antimicrobial and hemolytic actions. | FEBS Lett | 2003
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
>2000 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >2000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Deletion of two C-terminal Gln residues of 12-26-residue fragment of melittin improves its antimicrobial activity. | Peptides | 2005