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Peptide record

TPDB08014

Antibacterial Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB08014
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKKVLKAAA
Physicochemical Analysis
C80H140N20O17
RNDCEQGHIMFPSY
ALK
1654.12
11.00
4
0
10
+4
-0.60
0.627
150.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
332.50
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
4
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
15
C80H140N20O17
1654.12
11.00
+4
-0.60
0.627
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
<3 µM
Hemolytic Cytotoxic
50% Hemolysis | <3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro discriminative antipseudomonal properties resulting from acyl substitution of N-terminal sequence of dermaseptin s4 derivatives. | Chem Biol | 2007
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
20±1 µM
Hemolytic Cytotoxic
50% Hemolysis | 20±1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis